MicroRNAs in Lung Development and Disease

被引：41
作者：
Ameis, Dustin
Khoshgoo, Naghmeh
Iwasiow, Barbara M.
Snarr, Phillip
Keijzer, Richard
机构：
[1] Univ Manitoba, Dept Surg, Winnipeg, MB, Canada
[2] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada
[3] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada
[4] Childrens Hosp Res Inst Manitoba, Winnipeg, MB, Canada
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2017年 / 22卷
关键词：
MicroRNAs; gene expression; lung development; cystic fibrosis; asthma; bronchopulmonary dysplasia; CYSTIC-FIBROSIS; BRONCHOPULMONARY DYSPLASIA; NUCLEAR EXPORT; EXPRESSION; ASTHMA; TARGET; DYSREGULATION; PATHOGENESIS; REGULATOR; INFECTION;
D O I：
10.1016/j.prrv.2016.12.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
MicroRNAs (miRNAs) are small (similar to 22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia. (C) 2016 Published by Elsevier Ltd.
引用
收藏
页码：38 / 43
页数：6
相关论文
共 80 条
[31]   Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation [J].
Kumar, Manish ;
Ahmad, Tanveer ;
Sharma, Amit ;
Mabalirajan, Ulaganathan ;
Kulshreshtha, Ankur ;
Agrawal, Anurag ;
Ghosh, Balaram .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (05) :1077-U545
[32]   Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) [J].
Lai, C. K. W. ;
Beasley, R. ;
Crane, J. ;
Foliaki, S. ;
Shah, J. ;
Weiland, S. .
THORAX, 2009, 64 (06) :476-483
[33]   THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].
LEE, RC ;
FEINBAUM, RL ;
AMBROS, V .
CELL, 1993, 75 (05) :843-854
[34]   MicroRNA genes are transcribed by RNA polymerase II [J].
Lee, Y ;
Kim, M ;
Han, JJ ;
Yeom, KH ;
Lee, S ;
Baek, SH ;
Kim, VN .
EMBO JOURNAL, 2004, 23 (20) :4051-4060
[35]   Therapeutic targeting of microRNAs: current status and future challenges [J].
Li, Zhonghan ;
Rana, Tariq M. .
NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (08) :622-638
[36]   Profiling of miRNAs in pediatric asthma: Upregulation of miRNA-221 and miRNA-485-3p [J].
Liu, Feng ;
Qin, Hou-Bing ;
Xu, Bing ;
Zhou, Hui ;
Zhao, De-Yu .
MOLECULAR MEDICINE REPORTS, 2012, 6 (05) :1178-1182
[37]   Differential expression of components of the microRNA machinery during mouse organogenesis [J].
Lü, JI ;
Qian, J ;
Chen, F ;
Tang, XZ ;
Li, C ;
Cardoso, WV .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (02) :319-323
[38]   Impact of microRNA regulation on variation in human gene expression [J].
Lu, Jian ;
Clark, Andrew G. .
GENOME RESEARCH, 2012, 22 (07) :1243-1254
[39]   MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression [J].
Lu, Thomas X. ;
Munitz, Ariel ;
Rothenberg, Marc E. .
JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :4994-5002
[40]   Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells [J].
Lu, Yun ;
Thomson, J. Michael ;
Wong, Ho Yuen Frank ;
Hammond, Scott M. ;
Hogan, Brigid L. M. .
DEVELOPMENTAL BIOLOGY, 2007, 310 (02) :442-453
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