MicroRNAs in Lung Development and Disease

被引：41
作者：
Ameis, Dustin
Khoshgoo, Naghmeh
Iwasiow, Barbara M.
Snarr, Phillip
Keijzer, Richard
机构：
[1] Univ Manitoba, Dept Surg, Winnipeg, MB, Canada
[2] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada
[3] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada
[4] Childrens Hosp Res Inst Manitoba, Winnipeg, MB, Canada
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2017年 / 22卷
关键词：
MicroRNAs; gene expression; lung development; cystic fibrosis; asthma; bronchopulmonary dysplasia; CYSTIC-FIBROSIS; BRONCHOPULMONARY DYSPLASIA; NUCLEAR EXPORT; EXPRESSION; ASTHMA; TARGET; DYSREGULATION; PATHOGENESIS; REGULATOR; INFECTION;
D O I：
10.1016/j.prrv.2016.12.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
MicroRNAs (miRNAs) are small (similar to 22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia. (C) 2016 Published by Elsevier Ltd.
引用
收藏
页码：38 / 43
页数：6
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