Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

被引：0

作者：

Barra, Beatrice ^{[1
]}

Roux, Camille ^{[1
]}

Kaeser, Melanie ^{[1
]}

Schiavone, Giuseppe ^{[2
,3
]}

Lacour, Stephanie P. ^{[2
,3
]}

Bloch, Jocelyne ^{[6
]}

Courtine, Gregoire ^{[4
,5
]}

Rouiller, Eric M. ^{[1
]}

Schmidlin, Eric ^{[1
]}

Capogrosso, Marco ^{[1
]}

机构：

[1] Univ Fribourg, Dept Neurosci & Movement Sci, Platform Translat Neurosci, Fribourg, Switzerland

[2] Ecole Polytech Fed Lausanne EPFL, Ctr Neuroprosthet, Sch Engn, Inst Microengn, Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne EPFL, Ctr Neuroprosthet, Sch Engn, Inst Bioengn, Lausanne, Switzerland

[4] Ecole Polytech Fed Lausanne EPFL, Ctr Neuroprosthet, Lausanne, Switzerland

[5] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Sch Life Sci, Lausanne, Switzerland

[6] Ctr Hosp Univ Vaudois CHUV, Lausanne, Switzerland

来源：

2018 40TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2018年

基金：

瑞士国家科学基金会; 欧盟地平线“2020”;

关键词：

MOVEMENTS; MICROSTIMULATION; NEUROMODULATION; RESTORATION; PARALYSIS; DEFICITS; GAIT;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Notably, the application of stimulation bursts with spatiotemporal sequences that reproduce the natural activation of motoneurons restored skilled leg movements in rodent and nonhuman primate models of SCL Here, we studied whether this conceptual framework could be transferred to the design of cervical EES protocols for the recovery of reaching and grasping in nonhuman primates. We recorded muscle activity during a reaching and grasping task in a macaque monkey and found that this task involves a stereotypical spatiotemporal map of motoneuron activation. We then characterized the specificity of a spinal implant for the delivery of EES to cervical spinal segments in the same animal. Finally, we combined these results to design a simple stimulation protocol that may reproduce natural motoneuron activation and thus facilitate upper limb movements after injury.

引用

页码：1424 / 1427

页数：4