Role of lymph node density in predicting survival of patients with lymph node metastases after radical cystectomy: A multi-institutional study

被引：32

作者：

Osawa, Takahiro ^{[1
,2
]}

Abe, Takashige ^{[1
]}

Shinohara, Nobuo ^{[1
]}

Harabayashi, Toru ^{[1
]}

Sazawa, Ataru ^{[1
]}

Kubota, Kanako ^{[1
,3
]}

Matsuno, Yoshihiro ^{[3
]}

Shibata, Takeshi ^{[2
]}

Shinno, Yuichiro ^{[2
]}

Kamota, Shinji ^{[2
]}

Minami, Keita ^{[2
]}

Sakashita, Shigeo ^{[2
]}

Kumagai, Akira ^{[2
]}

Mori, Tatsuya ^{[2
]}

Nonomura, Katsuya ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Urol, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Urothelial Canc Res Grp, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ Hosp, Dept Surg Pathol, Sapporo, Hokkaido 060, Japan

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2009年 / 16卷 / 03期

关键词：

adjuvant chemotherapy; bladder cancer; lymph node density; lymph node metastasis; prognosis; TRANSITIONAL-CELL CARCINOMA; INVASIVE BLADDER-CANCER; PELVIC LYMPHADENECTOMY; URINARY-BLADDER; COMBINATION CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; POOLED ANALYSIS; IMPACT; INVOLVEMENT; DISSECTION;

D O I：

10.1111/j.1442-2042.2008.02221.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the prognostic role of different clinico-pathological parameters in node-positive patients treated by radical cystectomy. A retrospective multi-institutional study of 435 patients who underwent radical cystectomy between 1990 and 2005 was carried out. Of them, pathological lymph node (LN) metastases were found in 83 patients. Sixty of these 83 patients, whose clinical information and follow-up data were available, were included in the analysis. Twenty-five patients had undergone adjuvant chemotherapy, whereas 35 had not. A Cox proportional hazards model was used to determine the impact of the following clinico-pathological parameters on patient survival: number of resected LNs, number of positive LNs, LN density (defined as the ratio of the number of positive LNs divided by the total number of resected LNs) and adjuvant chemotherapy. Median follow-up for surviving patients was 41 months (range 4-138) after surgery. The median survival time for all patients was 22 months (95% confidence interval, 15-42 months). At multivariate analysis, LN density of 25% or less, adjuvant chemotherapy and pure urothelial carcinoma were independently significant predictors of survival. Lymph node density predicts survival in patients with node-positive bladder cancer.

引用

页码：274 / 278

页数：5

共 21 条

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