ATL3, a cargo receptor for reticulophagy

被引：21

作者：

Chen, Qingzhou ^{[1
]}

Teng, Junlin ^{[1
]}

Chen, Jianguo ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Membrane Biol, Key Lab Cell Proliferat & Differentiat, Coll Life Sci,Minist Educ, Beijing, Peoples R China

来源：

AUTOPHAGY | 2019年 / 15卷 / 08期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

ATL3; GABARAP; hereditary sensory and autonomic neuropathies type 1 (HSANI); reticulophagy receptors; selective autophagy;

D O I：

10.1080/15548627.2019.1609862

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum (ER) is the largest membranous organelle, and its turnover ensures cellular homeostasis. The selective macroautophagy/autophagy of the ER (reticulophagy) guarantees the balance of ER turnover. However, the mechanism and physiological relevance of reticulophagy is largely unknown. Recently, we identified ATL3 (atlastin GTPase 3), generally considered to mediate ER fusion, as a receptor for reticulophagy. ATL3 specifically interacts with the GABARAP subfamily proteins of the Atg8-family, and this association is crucial for ATL3's role as a receptor for reticulophagy. Moreover, 2 hereditary sensory and autonomic neuropathies type 1 (HSANI)-associated mutations of ATL3 (Tyr192Cys and Pro338Arg) impair ATL3's binding to GABARAP and function in reticulophagy. Therefore, we illuminate a new function of ATL3 in reticulophagy and the potential physiological relevance of reticulophagy in neurodegenerative diseases.

引用

页码：1465 / 1466

页数：2