Intravenous golimumab in rheumatoid arthritis

被引:9
|
作者
Cohen, Marc D. [1 ]
Keystone, Edward C. [2 ,3 ]
机构
[1] Mayo Clin, Denver, CO 80218 USA
[2] Univ Toronto, Toronto, ON, Canada
[3] Mt Sinai Hosp, Toronto, ON M5T 3L9, Canada
关键词
anti-TNF-; antibodies; golimumab; rheumatoid arthritis treatment; safety of TNF- inhibition; TNF-; inhibition; ALPHA MONOCLONAL-ANTIBODY; NECROSIS-FACTOR-ALPHA; DOUBLE-BLIND; PHASE-III; ANKYLOSING-SPONDYLITIS; METHOTREXATE THERAPY; SAFETY; EFFICACY; PHARMACOKINETICS;
D O I
10.1586/1744666X.2014.918847
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Intravenous golimumab in a dosage of 2 mg/kg, initially given every 4 weeks but then every 8 weeks, in addition to methotrexate, is effective in the treatment of patients with rheumatoid arthritis. This weight-based infusion is administered over thirty minutes with an acceptable safety profile. Since it is a relatively new formulation, more time will be required to assess its specific role in the rheumatologists' armamentarium and to appreciate more fully its long-term safety.
引用
收藏
页码:823 / 830
页数:8
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