Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty

被引：8

作者：

Antonio Suarez-Cuenca, Juan ^{[1
,2
]}

Robledo-Nolasco, Rogelio ^{[3
]}

Antonio Alcantara-Melendez, Marco ^{[3
]}

Diaz Hernandez, Luis Javier ^{[1
]}

Vera-Gomez, Eduardo ^{[1
]}

Hernandez-Patricio, Alejandro ^{[1
]}

Susana Sanchez-Naz, Karla ^{[1
]}

Ariel Buendia-Gutierrez, Juan ^{[1
]}

Contreras-Ramos, Alejandra ^{[4
]}

Sua Ruiz-Hernandez, Atzin ^{[1
]}

Perez-Cabeza de Vaca, Rebeca ^{[1
]}

Mondragon-Teran, Paul ^{[1
]}

机构：

[1] Ctr Med Nacl 20 Noviembre ISSSTE, Lab Expt Metab & Clin Res, Div Invest, Mexico City, DF, Mexico

[2] IMSS, Internal Med Dept, HGZ 58 Gral Manuel Avila Camacho, Mexico City, DF, Mexico

[3] Ctr Med Nacl 20 Noviembre ISSSTE, Cardiol Dept, Hemodynam Unit, Mexico City, DF, Mexico

[4] Hosp Infantil Mexico Dr Federico Gomez, Lab Biol Desarrollo & Teratogenesis Expt, Mexico City, DF, Mexico

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 07期

关键词：

EPCs; MACEs; Malondialdehyde; MMP-9; sICAM-1; SOD; BLOOD; OUTCOMES; THERAPY;

D O I：

10.1111/jcmm.14336

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis. Methods: The number of MPCs and soluble mediators such as IL-1 beta, sICAM-1, MMP-9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time-to-event and event free survival estimations. Results: Lower coronary circulating MPCs subpopulations CD45(+)CD34(+), CD45(+)CD34(+)CD133(+)CD184 , lower MMP-9 and higher sICAM-1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs. Conclusion: Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro-oxidative condition may be also associated.

引用

页码：4844 / 4849

页数：6

共 14 条

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