What can we learn from T2* maps of the cortex?

被引：58
作者：
Cohen-Adad, J. [1 ,2 ]
机构：
[1] Ecole Polytech Montreal, Inst Biomed Engn, Montreal, PQ, Canada
[2] Harvard Univ, Sch Med, MGH, AA Martinos Ctr Biomed Imaging, Charlestown, MA USA
来源：
NEUROIMAGE | 2014年 / 93卷
关键词：
T-2*; Cortex; Biomarker; Cytoarchitecture; Myeloarchitecture; Brodmann; HUMAN AUDITORY-CORTEX; HIGH-RESOLUTION MRI; HIGH-FIELD MRI; IN-VIVO VISUALIZATION; HUMAN CEREBRAL-CORTEX; NMR RELAXATION-TIMES; HUMAN BRAIN; MYELIN WATER; T; MULTIPLE-SCLEROSIS;
D O I：
10.1016/j.neuroimage.2013.01.023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Studies have shown that T-2* contrast can reveal features of cortical anatomy. However, understanding the relationship between T-2* contrast and the underlying cyto- and myelo-architecture is not an easy task, given the number of confounds, such as myelin, iron, blood vessels and structure orientation. Moreover, it is difficult to obtain reliable T-2* measurements in the cortex due to its thin and folded geometry and the presence of artifacts. This review addresses issues associated with T-2* mapping in the human cortex. After describing the theory behind T-2* relaxation, a list of practical steps is proposed to reliably acquire and process T-2* data and then map these values within the cortex using surface-based analysis. The last section addresses the question: "What can we gain from T-2* cortical mapping?", with particular emphasis on Brodmann mapping. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：189 / 200
页数：12
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