What can we learn from T2* maps of the cortex?

被引：58

作者：

Cohen-Adad, J. ^{[1
,2
]}

机构：

[1] Ecole Polytech Montreal, Inst Biomed Engn, Montreal, PQ, Canada

[2] Harvard Univ, Sch Med, MGH, AA Martinos Ctr Biomed Imaging, Charlestown, MA USA

来源：

NEUROIMAGE | 2014年 / 93卷

关键词：

T-2*; Cortex; Biomarker; Cytoarchitecture; Myeloarchitecture; Brodmann; HUMAN AUDITORY-CORTEX; HIGH-RESOLUTION MRI; HIGH-FIELD MRI; IN-VIVO VISUALIZATION; HUMAN CEREBRAL-CORTEX; NMR RELAXATION-TIMES; HUMAN BRAIN; MYELIN WATER; T; MULTIPLE-SCLEROSIS;

D O I：

10.1016/j.neuroimage.2013.01.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies have shown that T-2* contrast can reveal features of cortical anatomy. However, understanding the relationship between T-2* contrast and the underlying cyto- and myelo-architecture is not an easy task, given the number of confounds, such as myelin, iron, blood vessels and structure orientation. Moreover, it is difficult to obtain reliable T-2* measurements in the cortex due to its thin and folded geometry and the presence of artifacts. This review addresses issues associated with T-2* mapping in the human cortex. After describing the theory behind T-2* relaxation, a list of practical steps is proposed to reliably acquire and process T-2* data and then map these values within the cortex using surface-based analysis. The last section addresses the question: "What can we gain from T-2* cortical mapping?", with particular emphasis on Brodmann mapping. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：189 / 200

页数：12

共 133 条

[21] Characterization of White Matter Fiber Bundles With T2☆ Relaxometry and Diffusion Tensor Imaging [J].

Cherubini, Andrea ;

Peran, Patrice ;

Hagberg, Gisela Elisabeth ;

Varsi, Ambra Erika ;

Luccichenti, Giacomo ;

Caltagirone, Carlo ;

Sabatini, Umberto ;

Spalletta, Gianfranco .

MAGNETIC RESONANCE IN MEDICINE, 2009, 61 (05) :1066-1072

[22]

Clare S., 2001, P 10 ANN M ISMRM HON, P1465

[23] INVIVO MYELOARCHITECTONIC ANALYSIS OF HUMAN STRIATE AND EXTRASTRIATE CORTEX USING MAGNETIC-RESONANCE-IMAGING [J].

CLARK, VP ;

COURCHESNE, E ;

GRAFE, M .

CEREBRAL CORTEX, 1992, 2 (05) :417-424

[24] T2* mapping and Bo orientation-dependence at 7 T reveal cyto- and myeloarchitecture organization of the human cortex [J].

Cohen-Adad, J. ;

Polimeni, J. R. ;

Helmer, K. G. ;

Benner, T. ;

McNab, J. A. ;

Wald, L. L. ;

Rosen, B. R. ;

Mainero, C. .

NEUROIMAGE, 2012, 60 (02) :1006-1014

[25] In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: A surface-based analysis [J].

Cohen-Adad, J. ;

Benner, T. ;

Greve, D. ;

Kinkel, R. P. ;

Radding, A. ;

Fischl, B. ;

Rosen, B. R. ;

Mainero, C. .

NEUROIMAGE, 2011, 57 (01) :55-62

[26] CELLULAR-DISTRIBUTION OF TRANSFERRIN, FERRITIN, AND IRON IN NORMAL AND AGED HUMAN BRAINS [J].

CONNOR, JR ;

MENZIES, SL ;

STMARTIN, SM ;

MUFSON, EJ .

JOURNAL OF NEUROSCIENCE RESEARCH, 1990, 27 (04) :595-611

[27] Limits of detection of SPIO at 3.0 T using T2* relaxometry [J].

Dahnke, H ;

Schaeffter, T .

MAGNETIC RESONANCE IN MEDICINE, 2005, 53 (05) :1202-1206

[28] Cortical surface-based analysis - I. Segmentation and surface reconstruction [J].

Dale, AM ;

Fischl, B ;

Sereno, MI .

NEUROIMAGE, 1999, 9 (02) :179-194

[29] Toward in vivo histology: A comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2*-imaging at ultra-high magnetic field strength [J].

Deistung, Andreas ;

Schaefer, Andreas ;

Schweser, Ferdinand ;

Biedermann, Uta ;

Turner, Robert ;

Reichenbach, Juergen R. .

NEUROIMAGE, 2013, 65 :299-314

[30] The influence of white matter fibre orientation on MR signal phase and decay [J].

Denk, Christian ;

Hernandez Torres, Enedino ;

MacKay, Alex ;

Rauscher, Alexander .

NMR IN BIOMEDICINE, 2011, 24 (03) :246-252

← 1 2 3 4 5 6 7 8 9 10 →