Zinc-finger-based artificial transcription factors and their applications

被引：89

作者：

Sera, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Synth Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2009年 / 61卷 / 7-8期

关键词：

Artificial transcription factor; Zinc-finger proteins; DNA recognition; Gene regulation; Transcriptional effector domain; Gene therapy; Antiviral therapy; DNA-BINDING PROTEINS; HUMAN-IMMUNODEFICIENCY-VIRUS; ENDOGENOUS CHROMOSOMAL SITE; CONTROLLING GENE-EXPRESSION; CELL-PENETRATING PEPTIDES; IN-VITRO SELECTION; GROWTH-FACTOR-A; DRUG DISCOVERY; COMBINATORIAL LIBRARIES; HUMAN-PAPILLOMAVIRUS;

D O I：

10.1016/j.addr.2009.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Artificial transcription factors (ATFs) are potentially a powerful molecular tool to modulate endogenous target gene expression in living cells and organisms. To date, many DNA-binding molecules have been developed as the DNA-binding domains for ATFs. Among them, ATFs comprising Cys(2)His(2)-type zinc-finger proteins (ZFPs) as the DNA-binding domain have been extensively explored. The zinc-finger-based ATFs specifically recognize targeting sites in chromosomes and effectively up- and downregulate expression of their target genes not only in vitro, but also in vivo. In this review, after briefly introducing Cys(2)His(2)-type ZFPs, I will review the studies of endogenous human gene regulation by zinc-finger-based ATFs and other applications as well. (C) 2009 Elsevier BY. All rights reserved.

引用

页码：513 / 526

页数：14

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