Zinc-finger-based artificial transcription factors and their applications

被引：89

作者：

Sera, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Synth Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2009年 / 61卷 / 7-8期

关键词：

Artificial transcription factor; Zinc-finger proteins; DNA recognition; Gene regulation; Transcriptional effector domain; Gene therapy; Antiviral therapy; DNA-BINDING PROTEINS; HUMAN-IMMUNODEFICIENCY-VIRUS; ENDOGENOUS CHROMOSOMAL SITE; CONTROLLING GENE-EXPRESSION; CELL-PENETRATING PEPTIDES; IN-VITRO SELECTION; GROWTH-FACTOR-A; DRUG DISCOVERY; COMBINATORIAL LIBRARIES; HUMAN-PAPILLOMAVIRUS;

D O I：

10.1016/j.addr.2009.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Artificial transcription factors (ATFs) are potentially a powerful molecular tool to modulate endogenous target gene expression in living cells and organisms. To date, many DNA-binding molecules have been developed as the DNA-binding domains for ATFs. Among them, ATFs comprising Cys(2)His(2)-type zinc-finger proteins (ZFPs) as the DNA-binding domain have been extensively explored. The zinc-finger-based ATFs specifically recognize targeting sites in chromosomes and effectively up- and downregulate expression of their target genes not only in vitro, but also in vivo. In this review, after briefly introducing Cys(2)His(2)-type ZFPs, I will review the studies of endogenous human gene regulation by zinc-finger-based ATFs and other applications as well. (C) 2009 Elsevier BY. All rights reserved.

引用

页码：513 / 526

页数：14

共 114 条

[21] Advances in zinc finger engineering [J].

Choo, Y ;

Isalan, M .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (04) :411-416

[22] Synthesis of a new zinc finger peptide; comparison of its 'code' deduced and 'CASTing' derived binding sites [J].

Corbi, N ;

Perez, M ;

Maione, R ;

Passananti, C .

FEBS LETTERS, 1997, 417 (01) :71-74

[23] Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia [J].

Dai, QS ;

Huang, JH ;

Klitzman, B ;

Dong, CM ;

Goldschmidt-Clermont, PJ ;

March, KL ;

Rokovich, J ;

Johnstone, B ;

Rebar, EJ ;

Spratt, SK ;

Case, CC ;

Kontos, CD ;

Annex, BH .

CIRCULATION, 2004, 110 (16) :2467-2475

[24] Regulation of endogenous gene expression using small molecule-controlled engineered zinc-finger protein transcription factors [J].

Dent, C. L. ;

Lau, G. K. K. ;

Drake, E. A. ;

Yoon, A. ;

Case, C. C. ;

Gregory, P. D. .

GENE THERAPY, 2007, 14 (18) :1362-1369

[25]

DESHAYES S, 2005, ADV DRUG DELIV REV, V57, P637

[26] LENGTH-ENCODED MULTIPLEX BINDING-SITE DETERMINATION - APPLICATION TO ZINC-FINGER PROTEINS [J].

DESJARLAIS, JR ;

BERG, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :11099-11103

[27] USE OF A ZINC-FINGER CONSENSUS SEQUENCE FRAMEWORK AND SPECIFICITY RULES TO DESIGN SPECIFIC DNA-BINDING PROTEINS [J].

DESJARLAIS, JR ;

BERG, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2256-2260

[28] TOWARD RULES RELATING ZINC FINGER PROTEIN SEQUENCES AND DNA-BINDING SITE PREFERENCES [J].

DESJARLAIS, JR ;

BERG, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7345-7349

[29] Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors [J].

Dreier, B ;

Fuller, RP ;

Segal, DJ ;

Lund, CV ;

Blancafort, P ;

Huber, A ;

Koksch, B ;

Barbas, CF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35588-35597

[30] Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors [J].

Dreier, B ;

Beerli, RR ;

Segal, DJ ;

Flippin, JD ;

Barbas, CF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :29466-29478

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