Gastric per-oral endoscopic myotomy for refractory gastroparesis: results from the first multicenter study on endoscopic pyloromyotomy (with video)

被引:174
作者
Khashab, Mouen A. [1 ]
Ngamruengphong, Saowanee [1 ]
Carr-Locke, David [2 ]
Bapaye, Amol [4 ]
Benias, Petros C. [2 ]
Serouya, Sam [2 ]
Dorwat, Shivangi [4 ]
Chaves, Dalton M. [3 ]
Artifon, Everson [3 ]
de Moura, Eduardo G. [3 ]
Kumbhari, Vivek [1 ]
Chavez, Yamile Haito [1 ]
Bukhari, Majidah [1 ]
Hajiyeva, Gulara [1 ]
Ismail, Amr [1 ]
Chen, Yen-I. [1 ]
Chung, Hyunsoo [5 ]
机构
[1] Johns Hopkins Univ Hosp, Div Gastroenterol, Baltimore, MD 21287 USA
[2] Mt Sinai Beth Israel Med Ctr, Div Digest Dis, New York, NY USA
[3] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Gatrointestinal Endoscopy Unit, Sao Paulo, Brazil
[4] Deenanath Mangeshkar Hosp & Res Ctr, Shivanand Desai Ctr Digest Disorders, Pune, Maharashtra, India
[5] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea
关键词
BOTULINUM-TOXIN;
D O I
10.1016/j.gie.2016.06.048
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aims: Gastric per-oral endoscopic myotomy (G-POEM) recently has been reported as minimally invasive therapy for gastroparesis. The aims of this study were to report on the first multicenter experience with G-POEM and to assess the efficacy and safety of this novel procedure for patients with gastroparesis with symptoms refractory to medical therapy. Methods: All patients with gastroparesis who underwent endoscopic pyloromyotomy (G-POEM) at 5 medical centers were included. Procedures were performed following the same principles as esophageal POEM. Clinical response was defined as improvement in gastroparetic symptoms with absence of recurrent hospitalization. Adverse events were graded according to the American Society for Gastrointestinal Endoscopy lexicon. Results: A total of 30 patients with refractory gastroparesis (11 diabetic, 12 postsurgical, 7 idiopathic) underwent G-POEM. Previous therapies included Botox injection in 12, transpyloric stenting in 3, and PEG with jejunal extension (PEGJ) in 1. Nausea/vomiting were the predominant symptoms in 25 patients. Weight loss was present in 27 patients with an average of 10% loss of body weight. G-POEM was completed successfully in all 30 (100%) patients with a mean procedure time of 72 minutes (range, 35-223 min). The mean myotomy length was 2.6 +/- 2.3 cm. The mean length of hospital stay was 3.3 days (range, 1-12 days). Two adverse events occurred in 2 (6.7%) patients, including 1 capnoperitoneum and 1 prepyloric ulcer, rated as mild and severe, respectively. Clinical response was observed in 26 (86%) patients during a median follow-up of 5.5 months. Four patients (2 diabetic, 1 postsurgical, 1 idiopathic cause) did not respond to G-POEM. Repeat gastric emptying scan was obtained in 17 patients, normalized in 8 (47%), and improved in 6 (35%) patients. Conclusion: G-POEM is a technically feasible procedure. This small non-randomized study suggests the effectiveness of G-POEM for the treatment of patients with gastroparesis refractory to medical therapy. It concomitantly results in normalization of GES in a significant proportion of treated patients.
引用
收藏
页码:228 / 233
页数:6
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