Multidrug-resistance efflux pumps - not just for resistance

被引：1157

作者：

Piddock, Laura J. V. ^{[1
]}

机构：

[1] Univ Birmingham, Antimicrobial Agents Res Grp, Div Immun & Infect, Sch Med, Birmingham B15 2TT, W Midlands, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 08期

关键词：

D O I：

10.1038/nrmicro1464

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s). They can confer resistance to natural substances produced by the host, including bile, hormones and host-defence molecules. In addition, some efflux pumps of the resistance nodulation division (RND) family have been shown to have a role in the colonization and the persistence of bacteria in the host. Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them.

引用

页码：629 / 636

页数：8

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