Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497

被引：28

作者：

Ebada, Sherif S. ^{[1
,2
,6
]}

El-Neketi, Mona ^{[3
]}

Ebrahim, Weaam ^{[1
,3
]}

Mandi, Attila ^{[4
]}

Kurtan, Tibor ^{[4
]}

Kalscheuer, Rainer ^{[1
]}

Mueller, Werner E. G. ^{[5
]}

Proksch, Peter ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

[2] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt

[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[4] Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary

[5] Johannes Gutenberg Univ Mainz, Univ Med, Inst Physiol Chem, Duesbergweg 6, D-55128 Mainz, Germany

[6] Mutah Univ, Coll Pharm, Dept Pharmaceut Chem, Al Karak 61710, Jordan

来源：

PHYTOCHEMISTRY LETTERS | 2018年 / 24卷

关键词：

Aspergillus versicolor; Endophyte; Alkaloids; Antibacterial; Cytotoxicity; Tddft-ecd; A-D; MARINE; ALKALOIDS; NIDULANS; ISOCOUMARINS; DERIVATIVES; INHIBITORS; ISOLATE; GROWTH; DIMERS;

D O I：

10.1016/j.phytol.2018.01.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isocoumarin dimers (1 and 2) and one new dihydroquinolone derivative (3) were isolated from Aspergillus versicolor, an endophyte derived from leaves of the Egyptian water hyacinth Eichhornia crassipes (Pontederiaceae), together with ten other known metabolites. Chemical structures of the isolated metabolites were determined based on HRESIMS, extensive 1D and 2D NMR spectroscopy. The relative and absolute configurations of the new natural products were established by ROESY and electronic circular dichroism (ECD) spectroscopy, respectively. The axial chirality of the isocoumarin 7,7'-homodimers (1 and 2) was deduced by TDDFT-ECD calculations. All isolated compounds were assessed for their antimicrobial, antitubercular and cytotoxic activities. Several tested compounds revealed significant cytotoxic activity against mouse lymphoma L5178Y cell line with IC50 values ranging from < 0.36 to 16.3 mu M.

引用

页码：88 / 93

页数：6

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