Sulfated Laminaria japonica polysaccharides inhibit macrophage foam cell formation

被引：23
作者：
Li, Qiang-Ming [1 ]
Teng, Hao [1 ]
Zha, Xue-Qiang [1 ,2 ]
Pan, Li-Hua [1 ]
Luo, Jian-Ping [1 ]
机构：
[1] Hefei Univ Technol, Sch Food Sci & Engn, Hefei 230009, Anhui, Peoples R China
[2] Hefei Univ Technol, Sch Biol & Med Engn, Hefei 230009, Anhui, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 111卷
基金：
中国国家自然科学基金;
关键词：
Laminaria japonica; Polysaccharide; Sulfation; DENDROBIUM-HUOSHANENSE POLYSACCHARIDE; STRUCTURAL-CHARACTERIZATION; LIVER-INJURY; ANTIOXIDANT; BIOACTIVITY; EXTRACTION; MICE;
D O I：
10.1016/j.ijbiomac.2018.01.103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this work, a purified Laminaria japonica polysaccharide (LJP61A) was chemically modified to obtain three sulfated polysaccharides (SLJP1, SLJP2 and SLJP3) with different degrees of sulfation using the method of chlorosulfonic acid/pyridine. The effects and underlying mechanism of SLJP1, SLJP2 and SLJP3 on the suppression of macrophage foam cell formation were further investigated using the model of oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation. Results exhibited that the macrophage foam cell formation induced by ox-LDL could be significantly alleviated by these sulfated polysaccharides in a dose-dependent manner. Meanwhile, the enhancement of PPAR-gamma mRNA expression in ox-LDL induced macrophages was remarkably inhibited by these sulfated polysaccharides. Moreover, the cellular inflammation induced by ox-IDL could also be remarkably mitigated by these sulfated polysaccharides. These results indicated that the sulfated L. japonica polysaccharides could inhibit the conversion of macrophage into foam cell via obstructing PPAR-gamma activation and alleviating cellular inflammation. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：857 / 861
页数：5
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