A Peptide-Based Nanofibrous Hydrogel as a Promising DNA Nanovector for Optimizing the Efficacy of HIV Vaccine

被引：153

作者：

Tian, Yue ^{[1
,2
,3
]}

Wang, Huaimin ^{[4
,5
,6
]}

Liu, Ye ^{[7
]}

Mao, Lina ^{[4
,5
,6
]}

Chen, Wenwen ^{[1
,2
,3
]}

Zhu, Zhening ^{[1
,2
,3
]}

Liu, Wenwen ^{[1
,2
,3
]}

Zheng, Wenfu ^{[1
,2
]}

Zhao, Yuyun ^{[1
,2
]}

Kong, Deling ^{[4
,5
,6
]}

Yang, Zhimou ^{[4
,5
,6
]}

Zhang, Wei ^{[1
,2
]}

Shao, Yiming ^{[7
]}

Jiang, Xingyu ^{[1
,2
]}

机构：

[1] Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China

[2] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Nankai Univ, State Key Lab Med Chem Biol, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China

[5] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

[6] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

[7] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing 102206, Peoples R China

来源：

NANO LETTERS | 2014年 / 14卷 / 03期

基金：

美国国家科学基金会;

关键词：

Peptide-based nanofibrous hydrogel; HIV DNA vaccine; DNA condensation; immune response; safety evaluation; POTENT DELIVERY-SYSTEM; T-CELL RESPONSES; IMMUNE-RESPONSES; PLASMID DNA; PLGA MICROSPHERES; PEI/DNA COMPLEXES; DENDRITIC CELLS; SMALL MOLECULES; VIRUS; ADJUVANT;

D O I：

10.1021/nl404560v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This report shows that a nanovector composed of peptide-based nanofibrous hydrogel can condense DNA to result in strong immune responses against HIV. This nanovector can strongly activate both humoral and cellular immune responses to a balanced level rarely reported in previous studies, which is crucial for HIV prevention and therapy. In addition, this nanovector shows good biosafety in vitro and in vivo. Detailed characterizations show that the nanofibrous structure of the hydrogel is critical for the dramatically improved immune responses compared to existing materials. This peptide-based nanofibrous hydrogel shows great potential for efficacious HIV DNA vaccines and can be potentially used for delivering other vaccines and drugs.

引用

页码：1439 / 1445

页数：7

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