Synthetic Procedures Leading towards Aminobisphosphonates

被引：36

作者：

Chmielewska, Ewa ^{[1
]}

Kafarski, Pawel ^{[1
]}

机构：

[1] Wroclaw Univ Sci & Technol, Fac Chem, Dept Bioorgan Chem, PL-50370 Wroclaw, Poland

来源：

MOLECULES | 2016年 / 21卷 / 11期

关键词：

bisphosphonates; bisphosphonylation procedures; Vilsmayer-Haack-like reactions; functionalization of aminoalkylbisphosphonates; FARNESYL PYROPHOSPHATE SYNTHASE; BIOLOGICAL EVALUATION; IN-VITRO; AMINOMETHYLENE BISPHOSPHONATES; PHOSPHORUS TRICHLORIDE; OSTEOTROPIC PRODRUGS; EFFECTIVE INHIBITORS; EFFICIENT SYNTHESIS; ACID-DERIVATIVES; BONE;

D O I：

10.3390/molecules21111474

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents.

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页数：26

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