Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi

被引：42
作者：
Snove, Ola, Jr.
Rossi, John J.
机构：
[1] Beckman Res Inst City Hope, Div Mol Biol, Pasadena, CA 91101 USA
[2] Interagon AS, NO-7006 Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Fac Med, Dept Canc Res & Mol Med, NO-7006 Trondheim, Norway
来源：
GENOME BIOLOGY | 2006年 / 7卷 / 08期
关键词：
D O I：
10.1186/gb-2006-7-8-231
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?.
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页数：5
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