Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease

被引：24

作者：

Jazaeri, Amir A. ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, W Norman Thornton Div Gynecol Oncol, Dept Obstet & Gynecol, Charlottesville, VA 22908 USA

来源：

MOLECULAR ONCOLOGY | 2009年 / 3卷 / 02期

关键词：

BRCA1; BRCA2; Ovarian cancer; Breast cancer; Microarray; Fanconi anemia; GENE-EXPRESSION PROFILES; PROMOTER HYPERMETHYLATION; IMPROVED SURVIVAL; SPORADIC BREAST; BRCA2; MUTATIONS; HELICASE BRIP1; DNA-DAMAGE; CARRIERS; PATHWAY; RISKS;

D O I：

10.1016/j.molonc.2009.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian cancers and comprise 10% of total cases. Ovarian cancers arising from these mutations exhibit both overlapping and distinct clinical and molecular features. The expression profiles of sporadic ovarian cancers show similarities to those of BRCA1 and BRCA2-related tumors suggesting that BRCA-related pathways may be involved in their development as well. The purpose of this review is to consider the available data on ovarian cancers in the context of other investigations of BRCA-related transcriptional alterations, and highlight areas for future research. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：151 / 156

页数：6

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