NIR-Remote Selected Activation Gene Expression in Living Cells by Upconverting Microrods

被引：44

作者：

Zheng, Bin ^{[1
]}

Su, Lin ^{[2
]}

Pan, Huizhuo ^{[1
]}

Hou, Beibei ^{[2
]}

Zhang, Ying ^{[1
]}

Zhou, Fang ^{[2
]}

Wu, Xiaoli ^{[1
]}

Gong, Xiaoqun ^{[1
]}

Wang, Hanjie ^{[1
]}

Chang, Jin ^{[1
]}

机构：

[1] Tianjin Univ, Sch Life Sci, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, 92 Weijin Rd, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 04期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; LIGHT-TRIGGERED RELEASE; PHOTODYNAMIC THERAPY; MAMMALIAN-CELLS; ULTRAVIOLET; MICELLES; ADHESION; TISSUES;

D O I：

10.1002/adma.201503961

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An NIR-controlled gene expression system based on upconverting rods (UCRs) is demonstrated. The UCRs can harvest the "biocompatible" NIR light and convert it into local UV light, resulting in cleavage of the photosensitive mole cule (4-(hydroxymethyl)-3-nitrobenzoic acid, ONA) and on-demand release of gene carriers, thus realizing target gene expression at high spatial and temporal resolutions.

引用

页码：707 / 714

页数：8

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