On light sharing TOF-PET modules with depth of interaction and 157 ps FWHM coincidence time resolution

被引:75
作者
Pizzichemi, M. [1 ]
Polesel, A. [1 ,2 ]
Stringhini, G. [1 ,2 ]
Gundacker, S. [1 ,2 ]
Lecoq, P. [1 ]
Tavernier, S. [3 ,4 ]
Paganoni, M. [2 ]
Auffray, E. [1 ]
机构
[1] CERN, Geneva, Switzerland
[2] Univ Milano Bicocca, Milan, Italy
[3] Lab Instrumentacao & Fis Expt Particulas, Lisbon, Portugal
[4] Vrije Univ Brussel, Brussels, Belgium
基金
欧盟地平线“2020”;
关键词
time of flight positron emission tomography; depth of interaction; time resolution; time resolution of 10 ps; high resolution PET system; OF-FLIGHT; INTERACTION DETECTOR; CRYSTAL ARRAY; DOI DETECTOR; LYSO; SCINTILLATORS; READOUT; DESIGN; LENGTH;
D O I
10.1088/1361-6560/ab2cb0
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The performance of a light sharing and recirculation mechanism that allows the extraction of depth of interaction (DOI) are investigated in this paper, with a particular focus on timing. In parallel, a method to optimize the coincidence time resolution (CTR) of PET detectors by use of the DOI information is proposed and tested. For these purposes, a dedicated 64-channels readout setup has been developed with intrinsic timing resolution of 16 ps FWHM. Several PET modules have been produced, based on LYSO:Ce scintillators and commercial silicon photomultiplier (SiPM) arrays, with 3 x 3 mm(2) individual SiPM size. The results show the possibility to achieve a timing resolution of 157 ps FWHM, combined with the already demonstrated spatial resolution of 1.5 mm FWHM, DOI resolution of 3 mm FWHM, and energy resolution of 9% FWHM at 511 keV, with 15 mm long crystals of section 1.53 x 1.53 mm(2) and 3.1 x 3.1 mm(2). At the same time, the extraction of the DOI coordinate has been demonstrated not to deteriorate the timing performance of the PET module.
引用
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页数:16
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