Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

被引：152

作者：

Alexander, M. S. ^{[3
]}

Anderson, K. D. ^{[4
]}

Biering-Sorensen, F. ^{[5
,6
]}

Blight, A. R. ^{[7
]}

Brannon, R. ^{[8
]}

Bryce, T. N. ^{[9
]}

Creasey, G. ^{[10
]}

Catz, A. ^{[11
]}

Curt, A. ^{[1
,2
]}

Donovan, W. ^{[12
]}

Ditunno, J. ^{[13
]}

Ellaway, P. ^{[14
]}

Finnerup, N. B. ^{[15
]}

Graves, D. E. ^{[16
]}

Haynes, B. A. ^{[17
]}

Heinemann, A. W. ^{[18
,19
]}

Jackson, A. B. ^{[3
]}

Johnston, M. V. ^{[20
]}

Kalpakjian, C. Z. ^{[21
]}

Kleitman, N. ^{[22
]}

Krassioukov, A. ^{[1
,2
]}

Krogh, K.

Lammertse, D. ^{[23
]}

Magasi, S. ^{[24
]}

Mulcahey, M. J. ^{[25
]}

Schurch, B. ^{[26
]}

Sherwood, A. ^{[8
]}

Steeves, J. D. ^{[1
,2
]}

Stiens, S. ^{[27
]}

Tulsky, D. S. ^{[28
]}

van Hedel, H. J. A. ^{[26
]}

Whiteneck, G. ^{[23
]}

机构：

[1] Univ British Columbia, ICORD, Vancouver, BC V5Z 1M9, Canada

[2] Vancouver Coastal Hlth, Vancouver, BC, Canada

[3] Univ Alabama Birmingham, Birmingham, AL USA

[4] Univ Calif Irvine, Irvine, CA USA

[5] Rigshosp, Ctr Neurosci, DK-2100 Copenhagen, Denmark

[6] Univ Copenhagen, Copenhagen, Denmark

[7] Acorda Therapeut, Hawthorne, NY USA

[8] NIDRR, Washington, DC USA

[9] Mt Sinai Sch Med, New York, NY USA

[10] Stanford Univ, Palo Alto, CA 94304 USA

[11] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[12] Mem Hermann TIRR, Phys Med & Rehabil, Houston, TX USA

[13] Thomas Jefferson Univ, Philadelphia, PA 19107 USA

[14] Univ London Imperial Coll Sci Technol & Med, London, England

[15] Aarhus Univ Hosp, Danish Pain Res Ctr, DK-8000 Aarhus, Denmark

[16] Baylor Coll Med, Houston, TX 77030 USA

[17] Alseres Pharmaceut, Hopkinton, MA USA

[18] Northwestern Univ, Sch Med, Chicago, IL USA

[19] Rehabil Inst Chicago, Chicago, IL 60611 USA

[20] Univ Wisconsin, Milwaukee, WI 53201 USA

[21] Univ Michigan, Ann Arbor, MI 48109 USA

[22] NINDS, NIH, Bethesda, MD 20892 USA

[23] Craig Hosp, Englewood, CO USA

[24] Ctr Outcomes Res & Educ, Evanston, IL USA

[25] Shriners Hosp Crippled Children, Philadelphia, PA USA

[26] Balgrist Hosp, Zurich, Switzerland

[27] Vet Affairs Puget Sound Hlth Care, Seattle, WA USA

[28] Kessler Med Rehabil Res & Educ Ctr, W Orange, NJ USA

来源：

SPINAL CORD | 2009年 / 47卷 / 08期

关键词：

outcome tools; upper and lower limb; diagnostic tools; spinal cord clinical trial targets; functional assessment; quality of life and community participation; CLINICAL-TRIALS; ICCP PANEL; PSYCHOMETRIC PROPERTIES; INDEPENDENCE MEASURE; VERSION III; PAIN; PARTICIPATION; GUIDELINES; CONDUCT; SCI;

D O I：

10.1038/sc.2009.18

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study design: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial. Spinal Cord (2009) 47, 582-591; doi: 10.1038/sc.2009.18; published online 21 April 2009

引用

页码：582 / 591

页数：10

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