HIV Transmission Through Breastfeeding: Still Possible in Developed Countries

被引:8
作者
Blumental, Sophie [1 ]
Ferster, Alina [2 ]
Van den Wijngaert, Sigi [3 ]
Lepage, Philippe [1 ]
机构
[1] Hop Univ Enfants Reine Fabiola, Pediat Infect Dis Unit, Brussels, Belgium
[2] Hop Univ Enfants Reine Fabiola, Hemato Oncol Unit, Brussels, Belgium
[3] Ctr Hosp Univ St Pierre, Microbiol Lab, Brussels, Belgium
关键词
HIV; breastfeeding; postnatal; infection; mother to child transmission; infant; IMMUNODEFICIENCY-VIRUS TYPE-1; TO-CHILD TRANSMISSION; POSTNATAL TRANSMISSION; PROSPECTIVE COHORT; MOTHER; INFECTION; RISK; WOMEN; MILK;
D O I
10.1542/peds.2013-3022
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We describe here the case of a 13-month-old boy who acquired HIV infection postnatally through breastfeeding in a developed country in 2012. His mother had regular pregnancy follow-up and was found to be seronegative for HIV on 2 consecutive screening tests (during pregnancy and just after delivery). However, 1 year later, diagnosis of HIV infection arose in both of them after a pediatric emergency department visit for bronchitis when unexplained hepatosplenomegaly and inflammatory syndrome were noted. The negative maternal viral load found just after delivery confirmed that the mother's sero-conversion occurred postnatally, which allowed for active HIV transmission during lactation and lack of the efficient preventive measures that have implemented in Belgium for years. We discuss this uncommon but still existing mode of HIV transmission in industrialized countries and highlight the importance of implementing new targeted health education interventions in addition to constant clinicians' awareness.
引用
收藏
页码:E875 / E879
页数:5
相关论文
共 34 条
[1]  
[Anonymous], MMWR MORB MORTAL WKL
[2]  
[Anonymous], HIV TRANSM BREASTF R
[3]  
[Anonymous], GLOB REP UNAIDS REP
[4]   Children Who Acquire HIV Infection Perinatally Are at Higher Risk of Early Death than Those Acquiring Infection through Breastmilk: A Meta-Analysis [J].
Becquet, Renaud ;
Marston, Milly ;
Dabis, Francois ;
Moulton, Lawrence H. ;
Gray, Glenda ;
Coovadia, Hoosen M. ;
Essex, Max ;
Ekouevi, Didier K. ;
Jackson, Debra ;
Coutsoudis, Anna ;
Kilewo, Charles ;
Leroy, Valeriane ;
Wiktor, Stefan Z. ;
Nduati, Ruth ;
Msellati, Philippe ;
Zaba, Basia ;
Ghys, Peter D. ;
Newell, Marie-Louise .
PLOS ONE, 2012, 7 (02)
[5]  
Centers for Disease Control (CDC), 1985, MMWR Morb Mortal Wkly Rep, V34, P721
[6]   The Detection of Acute HIV Infection [J].
Cohen, Myron S. ;
Gay, Cynthia L. ;
Busch, Michael P. ;
Hecht, Frederick M. .
JOURNAL OF INFECTIOUS DISEASES, 2010, 202 :S270-S277
[7]   Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study [J].
Coovadia, Hoosen M. ;
Rollins, Nigel C. ;
Bland, Ruth M. ;
Little, Kirsty ;
Coutsoudis, Anna ;
Bennish, Michael L. ;
Newell, Marie-Louise .
LANCET, 2007, 369 (9567) :1107-1116
[8]  
Coutsoudis A, 2004, J INFECT DIS, V189, P2154, DOI 10.1086/420834
[9]   Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa [J].
Coutsoudis, A ;
Pillay, K ;
Kuhn, L ;
Spooner, E ;
Tsai, WY ;
Coovadia, HM .
AIDS, 2001, 15 (03) :379-387
[10]   Prevention of mother-to-child HIV transmission in resource-poor countries - Translating research into policy and practice [J].
De Cock, KM ;
Fowler, MG ;
Mercier, E ;
de Vincenzi, I ;
Saba, J ;
Hoff, E ;
Alnwick, DJ ;
Rogers, M ;
Shaffer, N .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (09) :1175-1182