Synthesis of Amphiphilic Diblock Poly-amido-saccharides and Self-Assembly of Polymeric Nanostructures

被引：7
|
作者：
Varghese, Maria [1 ]
Sockett, Kaitlynn A. [1 ]
El-Arid, Sara [1 ]
Korunes-Miller, Jenny [2 ]
Guigner, Jean-Michel [3 ]
Grinsta, Mark W. [1 ,2 ]
机构：
[1] Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Sorbonne Univ, Inst Mineral Phys Mat & Cosmochim IMPMC, F-75252 Paris 05, France
来源：
MACROMOLECULES | 2022年 / 55卷 / 13期
关键词：
RING-OPENING POLYMERIZATION; BLOCK-COPOLYMERS; DRUG-DELIVERY; MICELLES; ACCESS; RAFT;
D O I：
10.1021/acs.macromol.2c00146
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We report the synthesis of diblock poly-amido-saccharides (PASs) by sequential addition of variably protected glucose and galactose monomers via living anionic ring-opening polymerization. Diblock polymers with varied polymer length, hydrophobic to hydrophilic ratio, and stereochemistry of hydrophilic component were synthesized, characterized by NMR, IR, and GPC. These amphiphilic polymers selfassemble in water to form nanoparticles as determined by DLS, SEM, and cryo-TEM. Amphiphilic polymers with glucose-PAS hydrophobic and galactose-PAS hydrophilic blocks and degree of polymerization of 100 (100-(Et)Glc(1)-(OH)Gal(3)diblock PAS) form spherical nanostructures and are non-cytotoxic.
引用
收藏
页码：5675 / 5684
页数：10
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