The association between older age and receipt of care and outcomes in patients with acute coronary syndromes: a cohort study of the Myocardial Ischaemia National Audit Project (MINAP)

被引：122

作者：

Zaman, M. Justin ^{[1
,2
]}

Stirling, Susan ^{[2
]}

Shepstone, Lee ^{[2
]}

Ryding, Alisdair ^{[3
,4
]}

Flather, Marcus ^{[2
]}

Bachmann, Max ^{[2
]}

Myint, Phyo Kyaw ^{[5
]}

机构：

[1] James Paget Univ Hosp, Dept Emergency Med, Gorleston On Sea NR31 6LA, Norfolk, England

[2] Univ E Anglia, Dept Med, Norwich NR4 7TJ, Norfolk, England

[3] Norfolk & Norwich Univ Hosp, Norwich, Norfolk, England

[4] James Paget Univ Hosp, Norwich, Norfolk, England

[5] Univ Aberdeen, Sch Med & Dent, Acad Ctr Appl Clin & Translat Res Ageing, Aberdeen, Scotland

来源：

EUROPEAN HEART JOURNAL | 2014年 / 35卷 / 23期

关键词：

Acute coronary syndrome; Age; Elderly; Prognosis;

D O I：

10.1093/eurheartj/ehu039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conservative strategy on time to death was investigated by age. Methods and results Using data from 155 818 patients in the national registry for ACS in England and Wales [the Myocardial Ischaemia National Audit Project (MINAP)], we found that older patients were incrementally less likely to receive secondary prevention medicines and intensive management for both ST-elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI). In STEMI patients >= 85 years, 55% received reperfusion compared with 84% in those aged 18 to < 65 [odds ratio 0.22 (95% CI 0.21, 0.24)]. Not receiving intensive management was associated with worse survival [mean follow-up 2.29 years (SD 1.42)] in all age groups (adjusted for sex, cardiovascular risk factors, co-morbidities, healthcare factors, and case severity), but there was an incremental reduction in survival benefit from intensive management with increasing age. In STEMI patients aged 18-64, 65-74, 75-84, and >= 85, adjusted hazard ratios (HRs) for all-cause mortality comparing conservative treatment to intensive management were 1.98 (1.78, 2.19), 1.65 (1.51, 1.80), 1.62 (1.52, 1.72), and 1.36 (1.27, 1.47), respectively. In NSTEMI patients, the respective HRs were 4.37 (4.00, 4.78), 3.76 (3.54, 3.99), 2.79 (2.67, 2.91), and 1.90 (1.77, 2.04). Conclusion We found an incremental reduction in the use of evidence-based therapies with increasing age using a national ACS registry cohort. While survival benefit from more intensive management reduced with older age, better survival was associated with intensive management at all ages highlighting the requirement to improve standard of care in older patients with ACS.

引用

页码：1551 / 1558

页数：8

共 32 条

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