Complete remission of Merkel cell carcinoma of the scalp with local and regional metastases after topical treatment with dinitrochlorbenzol

被引：21

作者：

Herrmann, G ^{[1
]}

Groth, W ^{[1
]}

Krieg, T ^{[1
]}

Mauch, C ^{[1
]}

机构：

[1] Univ Cologne, Klin & Poliklin Dermatol & Venerol, Dept Dermatol, D-50924 Cologne, Germany

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2004年 / 50卷 / 06期

关键词：

D O I：

10.1016/j.jaad.2003.11.049

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma (MCC) is a highly aggressive tumor with a high percentage of recurrence, metastatic spread, and mortality. Treatment of metastasized MCC is not standardized and prognosis of metastasized MCC is often poor. Current protocols recommend Surgery, adjuvant radiation therapy, and often lymph node dissection to prevent recurrences. A few sporadic reports of spontaneous regression of MCC suggest a so far not yet characterized role and potential of the immune system in controlling this tumor. We describe a 69-year-old man with extended inoperable MCC of the scalp including multiple local and regional metastases who responded with complete remission to 4 weekly treatments of topically applied immune-modulating dinitrochlorbenzol. Together with Subsequent irradiation, remission has now lasted for more than 1 year.

引用

页码：965 / 969

页数：5

共 18 条

[1] Merkel cell carcinoma of the head and neck: A retrospective case series
Brissett, AE
Olsen, KD
Kasperbauer, JL
Lewis, JE
Goellner, JR
Spotts, BE
Weaver, AL
Strome, SE
[J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2002, 24 (11): : 982 - 988
[2] AN ATTEMPT AT TOPICAL DNCB IMMUNOMODULATION IN ADVANCED MALIGNANT-MELANOMA
BUDZANOWSKA, E
PAWLICKI, M
[J]. TUMORI, 1988, 74 (05) : 519 - 522
[3] Complete spontaneous regression of Merkel cell carcinoma: A review of the 10 reported cases
Connelly, TJ
Cribier, B
Brown, TJ
Yanguas, I
[J]. DERMATOLOGIC SURGERY, 2000, 26 (09) : 853 - 856
[4] COTLAR AM, 1986, AM SURGEON, V52, P159
[5] Role of postoperative radiotherapy in the management of Merkel cell carcinoma
Eich, HT
Eich, D
Staar, S
Mauch, C
Stützer, H
Groth, W
Krieg, T
Müller, RP
[J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2002, 25 (01): : 50 - 56
[6] Fenig E, 1997, CANCER, V80, P881, DOI 10.1002/(SICI)1097-0142(19970901)80:5<881::AID-CNCR8>3.0.CO
[7] 2-O
[8] Merkel cell carcinoma
Goessling, W
McKee, PH
Mayer, RJ
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) : 588 - 598
[9] Two cases of Merkel cell carcinoma cured by intratumor injection of natural human tumor necrosis factor
Hata, Y
Matsuka, K
Ito, O
Matsuda, H
Furuichi, H
Konstantinos, A
Nuri, B
[J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 1997, 99 (02) : 547 - 553
[10] ILLIG L, 1984, ANTICANCER RES, V4, P293

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