Taxonomic revision of Gouania Jacq. (Rhamnaceae) is presented for the full extent of its range in North America, from Florida and Mexico through Central America to and including Panama, and the islands of the Caribbean region, including the Bahamas. Fifteen species are recognized, five of which are described and published as new: G. croatii A. Pool (Panama and Colombia), G. ferruginea A. Pool (Guatemala and Honduras), G. guiengolensis A. Pool (Oaxaca, Mexico), G. obamana A. Pool (Mexico, Guatemala, Belize, and Honduras), and G. pubidisca A. Pool (Mexico, Guatemala, El Salvador, and Nicaragua). Lectotypes are designated for Banisteria lupuloides L. [equivalent to G. lupuloides (L.) Urb.] (and the synonymous G. domingensis L.), G. colombiana Suess., G. glabriuscula Stokes, G. lupuloides var. aptera Urb., G. mexicana Sesse & Moc., G. mexicana Rose [equivalent to G. rosei Wiggins], G. paniculata Spreng., G. pubescens Poir. var. martinieensis Poir., G. pubescens var. pubescens, G. virgata Reissek var. virgata [equivalent to G. virgata var. guianensis Reissek], G. virgata var. brasiliensis Reissek, and Rhamnus polygama Jacq. [equivalent to G. polygama (Jacq.) Urb.] (and the synonymous G. tomentosa Jacq.). Epitypes are designated for B. lupuloides L. [equivalent to G. lupuloides] (and the synonymous G. domingensis L.), G. stipularis DC.,. and R. polygama Jacq. [equivalent to G. polygama] (and the synonymous G. tomentosa). A neotype is selected for R. domingensis Jacq. and a lectotype is designated for the equivalent name G. glabra Jacq.