The GABA(B) receptor antagonist CGP 36 742 and the nootropic oxiracetam facilitate the formation of long-term memory

被引：42
作者：
Mondadori, C [1 ]
Mobius, HJ [1 ]
Borkowski, J [1 ]
机构：
[1] CIBA GEIGY AG,PHARMACEUT RES DEPT,CH-4002 BASEL,SWITZERLAND
来源：
BEHAVIOURAL BRAIN RESEARCH | 1996年 / 77卷 / 1-2期
关键词：
CGP; 36; 742; GABA(B); oxiracetam; memory; mouse;
D O I：
10.1016/0166-4328(95)00222-7
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The memory-enhancing effects of a single treatment with the GABA, antagonist CGP 36 742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that in all probability these substances facilitate the formation of the long-term memory trace.
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页码：223 / 225
页数：3
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