Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

被引：176
作者：
Duong, Van-An [1 ]
Nguyen, Thi-Thao-Linh [2 ]
Maeng, Han-Joo [2 ]
机构：
[1] Ho Chi Minh City Univ Technol HUTECH, Ho Chi Minh City 700000, Vietnam
[2] Gachon Univ, Coll Pharm, 191 Hambakmoe Ro, Incheon 21936, South Korea
来源：
MOLECULES | 2020年 / 25卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
lipid nanoparticles; solvent injection; entrapment efficiency; diffusion; aqueous phase; organic phase; solid lipid; liquid lipid; emulsifier; IN-VITRO; TOPICAL DELIVERY; ORAL DELIVERY; TARGETED DELIVERY; LABORATORY-SCALE; ONDANSETRON HCL; BREAST-CANCER; SLN; FORMULATION; RELEASE;
D O I：
10.3390/molecules25204781
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.
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页数：36
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