Anti-inflammatory Sesquiterpenoids from a Sponge-Derived Fungus Acremonium sp.

被引：60

作者：

Zhang, Ping ^{[1
]}

Bao, Baoquan ^{[1
]}

Dang, Hung The ^{[1
]}

Hong, Jongki ^{[2
]}

Lee, Hye Ja ^{[3
]}

Yoo, Eun Sook ^{[3
]}

Bae, Kyung Sook ^{[4
]}

Jung, Jee H. ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[3] Cheju Natl Univ, Coll Med, Cheju 690756, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 02期

关键词：

BETA-TRANS-BERGAMOTENE; ANTITUMOR ANTIBIOTICS; ASCOCHLORIN; ASCOFURANONE; METABOLITES; CHEMISTRY; PEPTIDES;

D O I：

10.1021/np8006793

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the course of our search for bioactive metabolites from a sponge-derived fungus Acremonium sp., new sesquiterpenoids (1-4) were isolated along with known derivatives by bioactivity-guided fractionation. The unique cyclic skeleton of compounds 2 and 3 is unprecedented. The absolute configurations were determined by modified Mosher's method and CD spectroscopy, along with comparison of H-1 and C-13 NMR spectroscopic data and specific optical rotation values with those reported. The anti-inflammatory activity of the isolated compounds (1, 5, 7-13) was evaluated by measuring their inhibitory effects on the production of pro-inflammatory mediators (NO, IL-6, and TNF-alpha) in RAW 264.7 murine macrophage cells. Among the compounds tested, compounds 7 and 9 significantly inhibited the production of NO and TNF-alpha at the concentration of 100 mu M, while compounds 11 and 12 showed selective inhibition of NO production at the same concentration.

引用

页码：270 / 275

页数：6

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