Implications of new proteomics strategies for biology and medicine

被引：55

作者：

Domon, B ^{[1
]}

Broder, S ^{[1
]}

机构：

[1] Celera Genom, Rockville, MD 20850 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2004年 / 3卷 / 02期

关键词：

structural proteomics; functional proteomics; quantitative proteomics; mass spectrometry; medicine; oncology;

D O I：

10.1021/pr034082c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in proteomics have fundamentally changed the paradigm of discovery for drug targets and novel biomarkers. Proteomics methodologies currently used will be reviewed in this paper, including structural proteomics, quantitative proteomics, and functional proteomics. A strategy to identify differentially expressed cell surface proteins as monoclonal therapeutic targets in oncology will be discussed.

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页码：253 / 260

页数：8

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