Delivery of insulin from hydroxyapatite ceramic microspheres:: Preliminary in vivo studies

被引：33

作者：

Paul, W

Nesamony, J

Sharma, CP

机构：

[1] Sree Chitra Tirunal Inst Med Sci & Technol, Div Biosurface Technol, Thiruvananthapuram 695012, Kerala, India

[2] Govt Med Coll, Dept Pharmaceut Sci, Thiruvananthapuram 695011, Kerala, India

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 2002年 / 61卷 / 04期

关键词：

ceramic; hydroxyapatite; microspheres; insulin; drug release;

D O I：

10.1002/jbm.10213

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The major limiting factor in utilizing protein drugs for sustained delivery is the lack of suitable delivery systems. Ceramic hydroxyapatite microspheres are biocompatible and utilized for the purification of proteins. As a preliminary study, we have investigated the possibility of using hydorxyapatite ceramic microspheres loaded with insulin as an implantable delivery system in rats. With this limited test, it was shown-that the loaded insulin was active and able to suppress the blood glucose level in normal rats. (C) 2002 Wiley Periodicals, Inc.

引用

页码：660 / 662

页数：3

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