Site-specific incorporation of photoisomerizable azobenzene groups into ribonuclease S

被引：56

作者：

Liu, D ^{[1
]}

Karanicolas, J ^{[1
]}

Yu, C ^{[1
]}

Zhang, ZH ^{[1
]}

Woolley, GA ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT CHEM,TORONTO,ON M5S 3H6,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(97)10044-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of S-peptide analogues bearing phenylazophenylalanine (Pap) residues at positions 4, 8, and 11 are described. Noncovalent reassociation of the Pap-4 and Pap-11 peptides with S-protein reconstitutes ribonuclease activity. Photoisomerization of the Pap-4 peptide is found to modulate the enzyme activity. (C) 1997 Elsevier Science Ltd.

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页码：2677 / 2680

页数：4

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