Uncovering a New Step in Sliding Nucleosomes

被引：4
作者：
Bowman, Gregory D. [1 ]
机构：
[1] Johns Hopkins Univ, TC Jenkins Dept Biophys, 3400 N Charles St, Baltimore, MD 21218 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2019年 / 44卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.tibs.2019.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromatin remodelers are ATP-driven motors that pump double-stranded DNA around the histone core of the nucleosome. Recent work by Chen and coworkers (Li et al., Nature, 2019 and Yan et al., Nat. Struct. Mol. Biol., 2019) has revealed an unexpected intermediate where initial translocation involves only one of the two DNA strands.
引用
收藏
页码：643 / 645
页数：3
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