Promising Directions in Atherosclerosis Treatment Based on Epigenetic Regulation Using MicroRNAs and Long Noncoding RNAs

被引：39

作者：

Skuratovskaia, Dania ^{[1
]}

Vulf, Maria ^{[1
]}

Komar, Aleksandra ^{[1
]}

Kirienkova, Elena ^{[1
]}

Litvinova, Larisa ^{[1
]}

机构：

[1] Immanuel Kant Baltic Fed Univ, Lab Immunol & Cell Biotechnol, Kaliningrad 236016, Russia

来源：

BIOMOLECULES | 2019年 / 9卷 / 06期

关键词：

atherosclerosis; miRNA; siRNA; lncRNA; epigenetic; DNA METHYLTRANSFERASE 1; CARDIOVASCULAR-DISEASE; TRANSCRIPTIONAL REGULATION; CHOLESTEROL EFFLUX; METHYLATION; MIRNA; GENE; HISTONE; INFLAMMATION; MECHANISMS;

D O I：

10.3390/biom9060226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is one of the leading causes of mortality from cardiovascular disease (CVD) and is a chronic inflammatory disease of the middle and large arteries caused by a disruption of lipid metabolism. Noncoding RNA (ncRNA), including microRNA (miRNA), small interfering RNA (siRNA) and long noncoding RNA (lncRNA), was investigated for the treatment of atherosclerosis. Regulation of the expression of noncoding RNA targets the constituent element of the pathogenesis of atherosclerosis. Currently, miRNA therapy commonly employs miRNA antagonists and mimic compounds. In this review, attention is focused on approaches to correcting molecular disorders based on the genetic regulation of the transcription of key genes responsible for the development of atherosclerosis. Promising technologies were considered for the treatment of atherosclerosis, and examples are given for technologies that have been shown to be effective in clinical trials.

引用

页数：23

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