The immunoregulatory role of CD1d-restricted natural killer T cells in disease

被引：91

作者：

van der Vliet, HJJ

Molling, JW

von Blomberg, BME

Nishi, N

Kölgen, W

van den Eertwegh, AJM

Pinedo, HM

Giaccone, G

Scheper, RJ

机构：

[1] Vrije Univ Amsterdam, Ctr Med, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Ctr Med, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

[3] Kirin Brewery Co Ltd, Kirin Pharmaceut Co, Gunma, Japan

来源：

CLINICAL IMMUNOLOGY | 2004年 / 112卷 / 01期

关键词：

immunoregulatory; T cell; disease;

D O I：

10.1016/j.clim.2004.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoinumme, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：8 / 23

页数：16

共 205 条

[31] Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation [J].