New cytotoxic sesquiterpene lactones from Achillea cretica L. growing in Tunisia

被引：9

作者：

Hichri, Faycal ^{[1
,2
]}

Znati, Mansour ^{[2
]}

Bouajila, Jalloul ^{[3
]}

Ben Jannet, Hichem ^{[2
]}

机构：

[1] King Khalid Univ, Coll Sci Girls Abha, Dept Chem, Abha, Saudi Arabia

[2] Univ Monastir, Lab Chim Heterocycl Prod Nat & Reactivite, Equipe Chim Med & Prod Nat, Fac Sci Monastir, Monastir 5019, Tunisia

[3] Univ Toulouse, Univ Paul Sabatier, Lab IMRCP UMR CNRS 5623, Fac Pharm Toulouse, F-31062 Toulouse, France

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 04期

关键词：

Achillea cretica; sesquiterpenes; guaianolide; cytotoxic activity; MILLEFOLIUM L; ESSENTIAL OIL; ANTIOXIDANT; CONSTITUENTS; CLAVENNAE; EXTRACTS;

D O I：

10.1080/10286020.2017.1355362

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phytochemical study of Achillea cretica growing in Tunisia led to the isolation of two novel sesquiterpene lactones, which have been designated achicretin 1 and achicretin 2. Their chemical structures were further confirmed by mass spectroscopy (ESI-MS) and by extensive application of one-and two-dimensional NMR spectroscopy. The isolated compounds were tested for their cytotoxic activity against four human cancer cell lines, IGROV-1, OVCAR-3, MCF-7, and HCT-116 using the MTT assay. It has been found that achicretin 2 exhibited more potent inhibitory activity with IC50 = values of 14.0 +/- 1.0 and 16.0 +/- 2.0 mu M against OVCAR-3 and HCT-116 cells, respectively. [GRAPHICS] .

引用

页码：344 / 351

页数：8

共 23 条

[1] Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp millefolium Afan. (Asteraceae) [J].