Role of the lncRNA-p53 regulatory network in cancer

被引：127

作者：

Zhang, Ali ^{[1
]}

Xu, Min ^{[2
]}

Mo, Yin-Yuan ^{[3
,4
]}

机构：

[1] Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Jiangsu Univ, Affiliated Hosp, Dept Gastroenterol, Zhenjiang 212001, Peoples R China

[3] Univ Mississippi, Med Ctr, Dept Pharmacol Toxicol, Jackson, MS 39216 USA

[4] Univ Mississippi, Med Ctr, Inst Canc, Jackson, MS 39216 USA

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2014年 / 6卷 / 03期

关键词：

p53; lncRNA; gene regulation; tumor suppressor; oncogenes; LONG NONCODING RNA; PROSTATE-SPECIFIC GENE; TUMOR-SUPPRESSOR GENE; GROWTH ARREST; P53; NETWORK; DNA-DAMAGE; C-MYC; TRANSCRIPTION; ACTIVATION; MEG3;

D O I：

10.1093/jmcb/mju013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how lncRNAs serve as p53 regulators or p53 effectors. Further characterization of these p53-associated lncRNAs in cancer will provide a better understanding of lncRNA-mediated gene regulation in the p53 pathway. As a result, lncRNAs may prove to be valuable biomarkers for cancer diagnosis or potential targets for cancer therapy.

引用

页码：181 / 191

页数：11

共 105 条

[1] Senescence-associated lncRNAs: senescence-associated long noncoding RNAs [J].

Abdelmohsen, Kotb ;

Panda, Amaresh ;

Kang, Min-Ju ;

Xu, Jason ;

Selimyan, Roza ;

Yoon, Je-Hyun ;

Martindale, Jennifer L. ;

De, Supriyo ;

Wood, William H., III ;

Becker, Kevin G. ;

Gorospe, Myriam .

AGING CELL, 2013, 12 (05) :890-900

[2] lncRNAdb: a reference database for long noncoding RNAs [J].

Amaral, Paulo P. ;

Clark, Michael B. ;

Gascoigne, Dennis K. ;

Dinger, Marcel E. ;

Mattick, John S. .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D146-D151

[3] A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition [J].

Beltran, Manuel ;

Puig, Isabel ;

Pena, Cristina ;

Miguel Garcia, Jose ;

Belen Alvarez, Ana ;

Pena, Raul ;

Bonilla, Felix ;

Garcia de Herreros, Antonio .

GENES & DEVELOPMENT, 2008, 22 (06) :756-769

[4] A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression [J].

Bernard, Delphine ;

Prasanth, Kannanganattu V. ;

Tripathi, Vidisha ;

Colasse, Sabrina ;

Nakamura, Tetsuya ;

Xuan, Zhenyu ;

Zhang, Michael Q. ;

Sedel, Frederic ;

Jourdren, Laurent ;

Coulpier, Fanny ;

Triller, Antoine ;

Spector, David L. ;

Bessis, Alain .

EMBO JOURNAL, 2010, 29 (18) :3082-3093

[5] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[6] A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].

BROWN, CJ ;

BALLABIO, A ;

RUPERT, JL ;

LAFRENIERE, RG ;

GROMPE, M ;

TONLORENZI, R ;

WILLARD, HF .

NATURE, 1991, 349 (6304) :38-44

[7] THE HUMAN XIST GENE - ANALYSIS OF A 17 KB INACTIVE X-SPECIFIC RNA THAT CONTAINS CONSERVED REPEATS AND IS HIGHLY LOCALIZED WITHIN THE NUCLEUS [J].

BROWN, CJ ;

HENDRICH, BD ;

RUPERT, JL ;

LAFRENIERE, RG ;

XING, Y ;

LAWRENCE, J ;

WILLARD, HF .

CELL, 1992, 71 (03) :527-542

[8] NONCODE v3.0: integrative annotation of long noncoding RNAs [J].

Bu, Dechao ;

Yu, Kuntao ;

Sun, Silong ;

Xie, Chaoyong ;

Skogerbo, Geir ;

Miao, Ruoyu ;

Xiao, Hui ;

Liao, Qi ;

Luo, Haitao ;

Zhao, Guoguang ;

Zhao, Haitao ;

Liu, Zhiyong ;

Liu, Changning ;

Chen, Runsheng ;

Zhao, Yi .

NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) :D210-D215

[9] Functional and Mechanistic Diversity of Distal Transcription Enhancers [J].

Bulger, Michael ;

Groudine, Mark .

CELL, 2011, 144 (03) :327-339

[10] MicroRNA-211 Expression Promotes Colorectal Cancer Cell Growth In Vitro and In Vivo by Targeting Tumor Suppressor CHD5 [J].

Cai, Chunxiao ;

Ashktorab, Hassan ;

Pang, Xiaowu ;

Zhao, Yuan ;

Sha, Wei ;

Liu, Yulan ;

Gu, Xinbin .

PLOS ONE, 2012, 7 (01)

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