Emerging role of extracellular vesicles in inflammatory diseases

被引：556

作者：

Buzas, Edit I. ^{[1
]}

Gyoergy, Bence ^{[1
]}

Nagy, Gyoergy ^{[2
]}

Falus, Andras ^{[1
]}

Gay, Steffen ^{[3
]}

机构：

[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[2] Polyclin Hospitaller Bros St John God, Dept Rheumatol, H-1023 Budapest, Hungary

[3] Univ Zurich Hosp, Clin Rheumatol, Ctr Expt Rheumatol, CH-8091 Zurich, Switzerland

来源：

NATURE REVIEWS RHEUMATOLOGY | 2014年 / 10卷 / 06期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL-DERIVED MICROPARTICLES; COLLAGEN-INDUCED ARTHRITIS; EXOSOME-LIKE VESICLES; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; DENDRITIC CELLS; RHEUMATOID-ARTHRITIS; MEMBRANE-VESICLES; SYNOVIAL FIBROBLASTS;

D O I：

10.1038/nrrheum.2014.19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery that submicron- sized extracellular vesicles (EVs) are generated by both prokaryotic and eukaryotic cells might have a profound effect on experimental and clinical sciences, and could pave the way for new strategies to combat various diseases. EVs are carriers of pathogen- associated and damage-associated molecular patterns, cytokines, autoantigens and tissue- degrading enzymes. In addition to a possible role in the pathogenesis of a number of inflammatory conditions, such as infections and autoimmune diseases, EVs, including microvesicles (also known as microparticles), exosomes and apoptotic vesicles, have therapeutic potential and might be used as biomarkers for inflammatory diseases. Therefore, molecular diagnostics and targeted therapy could benefit from expanding knowledge in the field. In this Review, we summarize important developments and propose that extracellular vesicles could be used as therapeutic vehicles and as targets for the treatment and prevention of inflammatory diseases.

引用

页码：356 / 364

页数：9

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