Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579

被引：90

作者：

Isaka, Masahiko ^{[1
]}

Prathumpai, Wai ^{[1
]}

Wongsa, Patcharaporn ^{[1
]}

Tanticharoen, Morakot ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol, BIOTEC, Pathum Thani 12120, Thailand

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 13期

关键词：

D O I：

10.1021/ol060926x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hirsutellone F (7), a novel alkaloid dimer, was isolated together with known monomers, hirsutellones A (1), B (2), and C (3), from the seed fungus Trichoderma sp. BCC 7579. The structure of 7 was elucidated by spectroscopic analysis. Studies on biomimetic chemistry, using the dimer 7, suggested that compound 8 (17,1'-dehydrohirsutellone B) should be the precursor for all hirsutellones.

引用

页码：2815 / 2817

页数：3

共 9 条

[1] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[2] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[3] Pyrrocidines A and B, new antibiotics produced by a filamentous fungus [J].

He, HY ;

Yang, HY ;

Bigelis, R ;

Solum, EH ;

Greenstein, M ;

Carter, GT .

TETRAHEDRON LETTERS, 2002, 43 (09) :1633-1636

[4] Bioactive substances from insect pathogenic fungi [J].

Isaka, M ;

Kittakoop, P ;

Kirtikara, K ;

Hywel-Jones, NL ;

Thebtaranonth, Y .

ACCOUNTS OF CHEMICAL RESEARCH, 2005, 38 (10) :813-823

[5] Hirsutellones A-E, antimycobacterial alkaloids from the insect pathogenic fungus Hirsutella nivea BCC 2594 [J].

Isaka, M ;

Rugseree, N ;

Maithip, P ;

Kongsaeree, P ;

Prabpai, S ;

Thebtaranonth, Y .

TETRAHEDRON, 2005, 61 (23) :5577-5583

[6] Unique diketopiperazine dimers from the insect pathogenic fungus Verticillium hemipterigenum BCC 1449 [J].

Isaka, M ;

Palasarn, S ;

Rachtawee, P ;

Vimuttipong, S ;

Kongsaeree, P .

ORGANIC LETTERS, 2005, 7 (11) :2257-2260

[7]

Koizumi F., 2001, Kokat Tokkyo Koho Japanese Patent, Patent No. [2001247574 A2, 2001247574, 2001 247, 574]

[8] Biosynthesis of structurally unique fungal metabolite GKK1032A2:: Indication of novel carbocyclic formation mechanism in polyketide biosynthesis [J].

Oikawa, H .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (09) :3552-3557

[9]

Yoshida M., 2001, 43 S CHEM NAT PROD S, P467

← 1 →