Sennidin stimulates glucose incorporation in rat adipocytes

被引：9

作者：

Abe, Daigo ^{[1
]}

Saito, Takeshi ^{[1
]}

Sekiya, Keizo ^{[1
]}

机构：

[1] Natl Agr Res Ctr Western Reg, Kagawa 7658508, Japan

来源：

LIFE SCIENCES | 2006年 / 79卷 / 11期

关键词：

insulin; insulin mimetic; oriental medical plant; sennidin; glucose transport; wortmannin; Akt; glucose transporter 4;

D O I：

10.1016/j.lfs.2006.03.007

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel small molecule compound which exerts insulin mimetic is desirable. Dozens of natural products that have quinone, naphthoquinone, or anthraquinone structure, were tested by a glucose incorporation assay. We found that sennidin A, anthraquinone derivative, stimulated glucose incorporation to near level of maximal insulin-stimulated and sennidin B, a stereoisomer of sennidin A, also stimulated, but the activity of sennidin B was lower than sennidin A. Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Our results suggest that in rat adipocytes, sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent, but in the IR/IRS1-independent manner. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1027 / 1033

页数：7

共 37 条

[31] Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators [J].

Qureshi, SA ;

Ding, V ;

Li, ZH ;

Szalkowski, D ;

Biazzo-Ashnault, DE ;

Xie, D ;

Saperstein, R ;

Brady, E ;

Huskey, S ;

Shen, XL ;

Liu, K ;

Xu, LB ;

Salituro, GM ;

Heck, JV ;

Moller, DE ;

Jones, AB ;

Zhang, BB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36590-36595

[32]

RODBELL M, 1964, J BIOL CHEM, V239, P375

[33] Sphingomyelinase stimulates 2-deoxyglucose uptake by skeletal muscle [J].

Turinsky, J ;

Nagel, GW ;

Elmendorf, JS ;

DamrauAbney, A ;

Smith, TR .

BIOCHEMICAL JOURNAL, 1996, 313 :215-222

[34] Dopants adsorbed as single atoms prevent degradation of catalysts (vol 3, pg 143, 2004) [J].

Wang, SW ;

Borisevich, AY ;

Rashkeev, SN ;

Glazoff, MV ;

Sohlberg, K ;

Pennycook, SJ ;

Pantelides, ST .

NATURE MATERIALS, 2004, 3 (04) :274-274

[35]

WHITE MF, 1994, J BIOL CHEM, V269, P1

[36] Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes [J].

Wu-Wong, JSR ;

Berg, CE ;

Wang, JH ;

Chiou, WJ ;

Fissel, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (12) :8103-8110

[37] Discovery of a small molecule insulin mimetic with antidiabetic activity in mice [J].

Zhang, B ;

Salituro, G ;

Szalkowski, D ;

Li, ZH ;

Zhang, Y ;

Royo, I ;

Vilella, D ;

Díez, MT ;

Pelaez, F ;

Ruby, C ;

Kendall, RL ;

Mao, XZ ;

Griffin, P ;

Calaycay, J ;

Zierath, JR ;

Heck, JV ;

Smith, RG ;

Moller, DE .

SCIENCE, 1999, 284 (5416) :974-977

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