Sennidin stimulates glucose incorporation in rat adipocytes

被引：9

作者：

Abe, Daigo ^{[1
]}

Saito, Takeshi ^{[1
]}

Sekiya, Keizo ^{[1
]}

机构：

[1] Natl Agr Res Ctr Western Reg, Kagawa 7658508, Japan

来源：

LIFE SCIENCES | 2006年 / 79卷 / 11期

关键词：

insulin; insulin mimetic; oriental medical plant; sennidin; glucose transport; wortmannin; Akt; glucose transporter 4;

D O I：

10.1016/j.lfs.2006.03.007

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel small molecule compound which exerts insulin mimetic is desirable. Dozens of natural products that have quinone, naphthoquinone, or anthraquinone structure, were tested by a glucose incorporation assay. We found that sennidin A, anthraquinone derivative, stimulated glucose incorporation to near level of maximal insulin-stimulated and sennidin B, a stereoisomer of sennidin A, also stimulated, but the activity of sennidin B was lower than sennidin A. Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Our results suggest that in rat adipocytes, sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent, but in the IR/IRS1-independent manner. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1027 / 1033

页数：7

共 37 条

[1] PREPARATION AND PROPERTIES OF PLASMA MEMBRANE AND ENDOPLASMIC RETICULUM FRAGMENTS FROM ISOLATED RAT FAT CELLS [J].