The Attenuation of Lung Ischemia Reperfusion Injury by Oxymatrine

被引：26
作者：
Zhu, Bing [1 ]
Yang, Jian-Ru [2 ]
Chen, Shi-Feng [1 ]
Jiang, Yue Quan [1 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiothorac Surg, Chongqing 400010, Peoples R China
[2] 6 Hosp Handan, Cent Lab, Handan 056000, Hebei, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 70卷 / 01期
关键词：
Lung ischemia reperfusion injury; Oxymatrine; TNF-alpha; IL-8; IL-10;
D O I：
10.1007/s12013-014-9917-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the protective effects of oxymatrine (OMT) on lung ischemia reperfusion injury (LIRI) in rabbits, models of LIRI in rabbit were used. Thirty-two rabbits were randomly divided into four groups: control group (n = 8), ischemia reperfusion group (I/R group, n = 8), OMTl group (n = 8), OMT2 group (n = 8). Lung tissue samples were collected at 40, 80, 120 min time-points after lung ischemia reperfusion. TNF-alpha, 1I-8, IL-10, apoptosis index (AI), and index of quantitative assessment of histologic lung injury (IQA) were measured in each group. TNF-alpha and IL-8 in I/R group were significantly higher than those of the control group and OMT2 group (P < 0.01), but in OMT2 group they were significantly lower than those of OMTl group (P < 0.05). IL-10 in OMT2 group and OMTl group was significantly higher than that of I/R group (P < 0.01). But in OMTl group it was significantly lower than that of OMT2 group (P < 0.05). AI in I/R group was significantly higher than that of OMT2 group and the control group at 80 min after lung ischemia reperfusion (P < 0.01). IQA in OMTl group and OMT2 group was significantly lower than that of the I/R group (P < 0.01). Oxymatrine can protect against LIRI in rabbits by upregulating levels of IL-10 and downregulating levels of TNF-alpha and IL-8, inhibiting the alveolar cells apoptosis and inflammatory response, and attenuating the acute LIRI.
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收藏
页码：333 / 336
页数：4
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