The role of oxidative stress in Alzheimer disease

被引:255
作者
Markesbery, WR
机构
[1] Univ Kentucky, Sanders Brown Ctr Aging, Dept Pathol, Med Ctr, Lexington, KY 40536 USA
[2] Univ Kentucky, Sanders Brown Ctr Aging, Dept Neurol, Med Ctr, Lexington, KY 40536 USA
关键词
D O I
10.1001/archneur.56.12.1449
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Increasing evidence demonstrates chat oxidative stress causes damage to cell function with aging and is involved in a number of age-related disorders including atherosclerosis, arthritis, and neurodegenerative disorders. In the neurodegenerative diseases, oxidative stress has been implicated in amyotrophic lateral sclerosis, Parkinson disease, Huntington disease, and Alzheimer disease (AD). The neurodegenerative disorder receiving the most attention has been AD, in which an increase occurs in oxidation of brain lipids, carbohydrates, proteins, and DNA. Some of the products of oxidation have been found in the major histopathologic alterations in AD: the neurofibrillary tangles (NFTs) and senile plaques (reviewed in Markesbery and Carney(1) and Ceballos-Picot(2)), These oxidative modifications are closely associated with a subtle inflammatory process in the brain in AD.
引用
收藏
页码:1449 / 1452
页数:4
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