Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease

被引：140
作者：
Bendheim, PE [1 ]
Poeggeler, B
Neria, E
Ziv, V
Pappolla, MA
Chain, DG
机构：
[1] Mindset Biopharmaceut Ltd, Jerusalem, Israel
[2] Univ Gottingen, D-3400 Gottingen, Germany
[3] Univ S Alabama, Mobile, AL 36688 USA
来源：
JOURNAL OF MOLECULAR NEUROSCIENCE | 2002年 / 19卷 / 1-2期
关键词：
Alzheimer's disease; beta-amyloid; oxidative stress; indole-3-propionic acid;
D O I：
10.1007/s12031-002-0036-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON(TM)) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.
引用
收藏
页码：213 / 217
页数：5
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