Tumor necrosis factor alpha gene rs1799724 polymorphism in Alzheimer's disease

被引：0

作者：

Atasever-Arslan, Belkis ^{[1
,2
]}

Ozer, Yagmur ^{[3
]}

Ozen, Fatih ^{[4
]}

Diler, Yunus ^{[5
]}

Yalcin, Ayse D. ^{[5
]}

机构：

[1] Uskudar Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkey

[2] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60607 USA

[3] Uskudar Univ, Hlth Sci Inst, Neurosci Program, Istanbul, Turkey

[4] Uskudar Univ, Fac Engn & Nat Sci, Dept Bioengn, Istanbul, Turkey

[5] Umraniye Res & Training Hosp, Neurol Clin, Istanbul, Turkey

来源：

GENERAL PHYSIOLOGY AND BIOPHYSICS | 2020年 / 39卷 / 06期

关键词：

TNF alpha; rs1799724; Alzheimer's disease; T2DM; TNF; ASSOCIATION; INFLAMMATION; C-857T; RISK;

D O I：

10.4149/gpb_2020031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurofibrillar tangles formed by the accumulation of hyperphosphorylated tau proteins in the intracellular space and the senile plaques formed by amyloid beta (A beta) accumulating in extracellular environment are shown as two main elements of Alzheimer's disease (AD). In our study, the relationship between the risk of Alzheimer's disease and TNF alpha rs1799724 polymorphism in the Turkish population was investigated. Our study is the first report investigating the relationship between the risk of Alzheimer's disease and TNF alpha rs1799724 gene polymorphism in Turkish population. No significant relation was found for rs1799724 polymorphism in AD patients. Since TNF alpha rs1799724 gene polymorphism was also associated with type 2 diabetes mellitus (T2DM), the polymorphism also was evaluated in T2DM within the AD patients group. According to our results rs1799724 polymorphism was found to be a significant relationship with T2DM within AD patients group. On the other hand, there was no significant difference between fasting blood glucose values of AD patients and -857C>T (rs1799724) polymorphism. According to our results, -857C>T rs1799724 polymorphism may have a relationship with T2DM as independent from AD.

引用

页码：595 / 599

页数：5

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