From structure to disease: The evolving tale of aquaporin biology

被引：745
作者：
King, LS
Kozono, D
Agre, P
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA
[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21224 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1469
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.
引用
收藏
页码：687 / 698
页数：12
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