The interplay between critical transcription factors and microRNAs in the control of normal and malignant myelopoiesis

被引：23
作者：
Stavast, Christiaan J. [1 ]
Leenen, Pieter J. M. [1 ]
Erkeland, Stefan J. [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Immunol, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands
来源：
CANCER LETTERS | 2018年 / 427卷
关键词：
Transcription factors; MicroRNA; Myelopoiesis; Acute Myeloid Leukemia; ACUTE MYELOID-LEUKEMIA; INTERFERON REGULATORY FACTOR-8; C/EBP-ALPHA; MACROPHAGE POLARIZATION; DENDRITIC CELLS; STEM-CELLS; NFI-A; EXPRESSION; KLF4; DIFFERENTIATION;
D O I：
10.1016/j.canlet.2018.04.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myelopoiesis is a complex process driven by essential transcription factors, including C/EBP alpha, PU.1, RUNX1, KLF4 and IRF8. Together, these factors are critical for the control of myeloid progenitor cell expansion and lineage determination in the development of granulocytes and monocytes/macrophages. MicroRNAs (miRNAs) are expressed in a cell type and lineage specific manner. There is increasing evidence that miRNAs fine-tune the expression of hematopoietic lineage-specific transcription factors and drive the lineage decisions of hematopoietic progenitor cells. In this review, we discuss recently discovered self-activating and feed-back mechanisms in which transcription factors and miRNAs interact during myeloid cell development. Furthermore, we delineate how some of these mechanisms are affected in acute myeloid leukemia (AML) and how disrupted transcription factor-miRNA interplays contribute to leukemogenesis. (C) 2018 The Authors. Published by Elsevier B.V.
引用
收藏
页码：28 / 37
页数：10
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