Replenishment of the podocyte compartment by parietal epithelial cells

被引：8

作者：

Kopp, Jeffrey B. ^{[1
]}

机构：

[1] NIDDKD, Kidney Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

KIDNEY INTERNATIONAL | 2015年 / 88卷 / 05期

关键词：

FOCAL SEGMENTAL GLOMERULOSCLEROSIS; RENAL PROGENITORS; DISEASE;

D O I：

10.1038/ki.2015.256

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

While progressive podocytopenia is a characteristic feature of chronic glomerular disease, the visceral epithelial niche can be replenished from the parietal epithelium. Two new reports demonstrate this process in genetically engineered mice, using fate mapping, and in human renal biopsies manifesting segmental glomerulosclerosis in diverse settings, using cellular and extracellular matrix markers.

引用

页码：934 / 935

页数：2

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