Evaluation for Protective Effect of Rutin, a Natural Flavonoid, against HCl/Ethanol-Induced Gastric Lesions

被引：9
作者：
Jeong, Choon Sik [1 ]
机构：
[1] Duksung Womens Univ, Dept Pharm, Seoul 132714, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2009年 / 17卷 / 02期
关键词：
Rutin; Anti-gastric activity; Antioxidant; Anti-Helicobacter pylori; HCl/ethanol-induced gastric lesion; HELICOBACTER-PYLORI; ANTIOXIDANT; AGENTS; CANCER; RATS;
D O I：
10.4062/biomolther.2009.17.2.199
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study we investigated the protective effects of rutin, a natural plant flavonoid, on HCl/ethanol-induced gastric lesions in rats. Rutin showed the antioxidant activities, the acid-neutralizing capacities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori.), which are equivalent to control compounds. In addition, rutin significantly inhibited HCl/ethanol-induced gastric lesions. Antigastritic action of rutin may be associated with the antioxidant activities, acid-neutralizing capacities, anti-H. pylori action, and the stimulation of mucus secretion. From these results, we could suggest that rutin may be useful for the treatment and/or protection of gastritis.
引用
收藏
页码：199 / 204
页数：6
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